RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
E2f1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; qRT-PCR; Western Blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination
Year
2021
Function
"RT-qRT-PCR analysis revealed a significantly increased E2F1 expression pattern in silicosis, which was highly positively correlated with the expression pattern of SKP2."